Study on the effect of streptokinase-activated plasmin (fibrinolysin) on clots in various stages of organization.
نویسندگان
چکیده
منابع مشابه
Immunohistochemical Study of Thrombolytic Mechanisms.
I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...
متن کاملBlood Clot Plasmin Antigen Specific Localization In
I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...
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Streptokinase produces it-s lytic effect by activation of a profibrinolysin usually called plasminogen. Many attempt-s have been made to isolate this latter material for investigation without consistent success.#{176}’ ‘#{176} A new method for preparation of this material (plasminogen)’t ‘ 12 has recently been reported. In vivo stu lies of activated plasminogen (plasmin) in dogs and rabhit-&3 h...
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The lysis and aspiration of a clotted hemothorax by means of an effective enzymatic agent is highly desirable. Various enzymes have been used for this purpose but alt have certain disadvantages. Trypsin has an irritative effect of pleural pain on injection and often shows a toxic reaction due to the enzyme or breakdown of protein products.’ The inhibitor (antitrypsin) normally present in the se...
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Although there is little doubt that more than one proteolytic enzyme occurs in plasma, plasmin (fibrinolysin) is the only such enzyme which has been definitely identified. Astrup and Permin,12 on the basis of differences in susceptibility to activation by streptokinase and fibrinokinase, have suggested that there are two precursors of fibrinolytic enzymes in human blood. They have designated th...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 37 6 شماره
صفحات -
تاریخ انتشار 1958